You spend more time on less topics: the variety of work is much lower, which some people love, and some people are frustrated by. There is often much less "drastic innovation", or when there is, it takes much longer than you might be used to in other industries. Favor is given to proven, predictable technologies and choices, even if that leaves some opportunities on the table.
That being said, it's something I often miss. The ability to have such solid confidence on the things you've built, and the ability to drop into nearly any piece of the system and have everything be consistent and predictable is a quality in itself. It makes debugging (often VERY rare) issues much more tractable, both at a higher systems level, as well as digging deeper into the code itself.