What do you consider 'meaningful work'? That can range the gamut of writing an app that helps cure orphans of cancer to working for Google and watching your code end up on killedbygoogle.com.
Is there something else outside of work that is attractive about where you live, or something outside of work locally that would fill time as a hobby, volunteering, <insert something else>?
(I find little meaning in the work I do, it'll all be trashed in a couple of years; nature does the trick, instead)