I encourage you to check out the OSX-PROXMOX project, which fully supports AMD and is designed to simplify these inside-a-VM setups (though not as much as a Docker setup). https://github.com/luchina-gabriel/OSX-PROXMOX

Also, there are a couple of kext projects that allow you to use AMD graphics, even iGPUs, on Hackintoshes. I have not tested this myself, but there are rumblings you may even be able to get this to work with a Steam Deck.

https://github.com/ChefKissInc/NootedRed

https://github.com/ChefKissInc/NootRX

A lot has changed in the Hackintosh space around AMD of late. I don’t think the automatic pessimism is as warranted as it once was.

i think for the most part the cpus should be ok. they do have different feature sets but the isa is the same. the platform chipset is a different topic i guess. they dont need to share any logic or semantics between amd/intel as those are controlled by drivers rather than having to execute programmer's machine code directly. not 100% on this, but x86_64 between amd and intel does share a lot of overlap right? if you dont go too far into extensions perhaps.

id guess vmxon and vmxoff and vmcs structures etc. will still be the same on both? a lot of security stuff etc. is totally different (amd psp vs intel ME etc.)

(still agree ofc, but just thinking about where these differences are located as the cpus can run very similar or the same code)