I do not use C-b as the tmux prefix key because it interferes with my muscle memory for Emacs where C-b invokes backward-char (i.e., move the cursor back by character(s)).
So I use C-j instead as the prefix key. While C-j also happens to be a useful Emacs key-binding, I use it quite rarely in Emacs. As a result, I do not have strong muscle memory for C-j and I can use it as the prefix key in tmux quite comfortably.
Here is my tiny .tmux.conf: https://github.com/susam/dotfiles/blob/main/.tmux.conf
Even without tmux, this can be an issue - a long time ago I was using the X windows "drag the selection" middle mouse button action and accidentally let go of the button while the cursor was over an emacs text window - I sent my first email to some big listserv I subscribed to consisting of weird fragments from the log file I was trying to paste.a
I sometimes like to program using Unicode variable names when doing physics/math, and this is an easy way to do so built into Emacs.
I use p in screen and tmux as prefix key. I usually prefer tmux.
I usually never do heavy editing in a tmux window. Rarely I use emacs in a terminal window these days. I use tramp to remote connect and edit comfortably in my X session.