and neither will the proposed treatments, and neither will the clinical trials, and neither will the approved drugs
My Theory: The reason that Dopamine fails is because they do not have low dopamine, but low energy for the dopamine receptor. The dopamine receptors are G Coupled Protein receptors that need GTP to function. So if you are low in the purine GTP then it does not matter how much dopamine you make.
Giving these patients dopamine works, but then fails, because it depletes the cells of GTP.
This is how science works.
*edit, for the record, for me, as a postdoc, a hypothesis, while more structured than mere speculation, is still an unproven explanation that requires rigorous testing and peer review before it can be considered established scientific knowledge, and thus remains speculative.
You’re a postdoc and you don’t think this is obvious? That’s what follows a hypothesis in the scientific process.
Make an observation or ask a question.
Gather background information.
Create a hypothesis. (You are here)
Create a prediction and perform a test.
Analyze the results and draw a conclusion.
Share the conclusion or decide what question to ask next: Document the results of your experiment.