Sure, shift counts. I suppose I would bind it to a more convenient keybinding if I used query-regexp-replace regularly, but note that I didn't say there weren't any such keybindings, just that they're rare.

I assume this varies widely across setups.

    (use-package visual-regexp
      :defer t
      :bind (("C-c r" . vr/replace)
             ("C-c q" . vr/query-replace)
             ("C-r" . vr/isearch-backward)
             ("C-s" . vr/isearch-forward)))

    (use-package visual-regexp-steroids
      :defer t)