It's probably better to say that engineering based on science is usually real. Engineering cares a lot less about falsifying theories and more on what existing theories seem to have general predictive value, and can be used to do stuff, including things where human lives are at risk (tall buildings, fire reduction materials, airplanes). And if there are failures out in the field, they're inspected, and those results are fed back to update both the practices, and the theories.
Personally I believe we live in an objective universe that can be understood by human brains (possibly using AI augmentation) and that our currently most advanced experimentally verified theories correspond to some actual true aspect of our universe. In that sense, science is real when the current theories match those aspects well enough to make generalizable predictions (general relativity and quantum mechanics).