You are mixing few different things here - yes AFAIK sherpas / tibetans have genes preselected to cope better with altitude, but there is absolutely 0 zilch nothing of such about 'crowded city or a submarine'.

WTF would that actually even be, submarines have cca surface pressure, maybe you meant adaptation to generally shitty soulless draining more stresful environments? Again, nothing like that out there in gene pool, city folks generally love running away to the nature as much as they can, at least those who already experienced how healing and recharging it can be and can afford it.