Yet they screen successfully for submariners and get a good crew. Their genes came from somewhere.

And every human in existence has been adapted over the last 50K years for tribal, village and city conditions. Early hominids were very different - hairier, loners, more fractious, used more calories, communicated less.

AMH (anatomically modern humans) have co-evolved with crowded conditions, to live in groups and tolerate each other without killing one another. So maybe three modifiers on that was hyperbole.