I am doing an accessibility audit for an application at work right now and I was tasked with getting things up to the WCAG AA level but I found that I had huge amounts of unused white space, even viewing it at 1024x768 desktop, and jacked font sizes up not to the "large type" levels of AAA but substantially larger which I think is easier for everyone, given the size of the UI controls information density is not going down a whole lot.