Excel shouldn't be used beyond the needs of an accountant.
Before some notes that the original hackers did actually that on some software like Maxima on top of MacLisp, a Lisp environment had a far better structure for doing specialized software than your 'office' suite mostly used to do paperwork.
If you used an XSL file for a million row census as it happened with the Coronavirus, you deserve to be either computer educated or hire some programmers to properly normalize that into either a MariaDB table or SQLite + some UI on top depending on the needs.
Everything else it's a recipe for a disaster.