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Definitely. I know RubyMotion currently supports XIBs and Storyboards, but yeah there's no integrated solution with Xcode or Instruments right now. I personally like the Rake-based approach, its more lightweight than booting up an IDE, but I would bet that better Xcode support is possible since MacRuby already does it pretty well.

Nitron has [slightly hacky] support for IB: https://github.com/mattgreen/nitron

Check the tutorial for an explanation of how to use it. Disclaimer: I'm the author. :)

That's if you like using interface builder. I personally dislike it and prefer to lay things out programmatically, but this probably has to do with the fact that I came to iOS development from the web development world.

I also try to not use IB most of the time, but especially if you are building not so custom designs, IB really increase the productivity and keep the code clean.