My major complaint is the heat and noise it creates when in a Google Meet (in Firefox though) and that I can not rely on the standby mode not draining the battery when I need the laptop. I also have problems with docked operation (TB4 dock), but I think these are likely Linux problems, so I won't hold it against the hardware.
I like the idea and philosophy of Frameworks being easy to service/disassemble and can attest to that fact. The exchangeable ports are great for in-office work (keep an HDMI for the meeting room, an USB-A port for your colleague's thumb drive in there), but for my work from home they are essentially useless. I just keep 2x USB-C and 2x USB-A, usually only one USB-C is used for the dock connector. Build quality and overall look and feel are decent as well, but of course this is personal preference.
I have a long history with ThinkPads and never ran into problems with them. I know that some of the laptops from the same batch as my most recent one have swollen batteries by now, but they could be swapped out, acceptable after about 5 years of daily use. If I had to chose a personal laptop now, I would very likely check in on Thinkpads again, I liked the T440p and T480 series. I also have a Legion model that is holding up fine. The Framework 16 looks interesting, so I would need to check that out as well.
P.S. I know there are tweaks and fixes for most of the problems above, some I have applied, some I haven't. I am ok with the current state.