I use Perl for one-liners all the time -- nothing can top it there.
But when the task at hand grows just slightly bigger, to the point where I know I'll need to pass filehandles to/from my own functions, my skin starts to literally itch because of how bad the filehandle situation is.
It's not plain "open F, ..." any more... Is it "*F"? Is it "\*F"? Are those the same thing? (What the hell is a "typeglob"?) Wait, can't I just use "open my $f" and everything works the way it obviously should? Well, kinda, unless you want to be able to store an existing filehandle like STDIN in there, then you have to do something different again... Do I need IO::Handle instead? (Why does that need to exist...?)