The downside is that you may be unable to sell it and actually have to take a course that you don’t want
So if you are planning to sell the slots and it does not work out, you just drop the course, no harm to you.
I won’t say no harm but you have to be pretty desperate to try to pull this off
It also just fucks with the University's ability to gauge class interest. In my university, if a class filled up early in the registration window, the University would try to increase capacity or add another copy of the class, but that's not always an option.
A reminder that this is not done for technical reasons. Plenty of colleges all across the US, big and small, custom-built registration software or purchased on the open market, have fully functional waitlist features. "first come first serve" is a policy choice.