Bigger caches. Making entire RAMFS or tmpfs partitions (filesystems but in RAM) for applications or tinkering with things. https://wiki.debian.org/ramfs , Virtualization / VMs, databases. Loading large files into RAM instead of having to read by row/column on a HD.
I'd rather have more RAM available unused than not have RAM available and need it. Been the general rule of thumb for me for the last 30ish years.