I could tolerate no graphic acceleration and battery issues as part of the virtualization overhead, but I had issues with sleep (it would sleep and wake up perfectly only with when plugged in) and other related problems such as Windows VMs crashing when waking up from sleep.
I was using it well at home but could not stand it when I travelled around with my laptop.
I think Xen is mostly at fault for the issues, but I’m sure using something like KVM would be insecure, or they would have migrated already.