It's not unthinkable, but in practise there's usually strong pressure in play: sunk cost fallacy, children to support, the threat of social ostracism. This is mostly true for wives rather than husbands because of female socialisation (this is sadly where gender actually becomes relevant!).

As the author himself says: "It turns out that I like women so much I’d like to be one of them"

That's not how sex works. I like women a lot too: liking them a lot doesn't mean you want to be one, that's called autogynephilia and can be treated with talking therapy.

However if it's a true expression of his attitudes and preferences then perhaps if his wife decided to masculinise her appearance e.g. injecting testosterone to deeper her voice, cause male-associated health growth, have elective surgical interventions like a double mastectomy, he wouldn't receive it as well as his wife seems to have. That's definitely speculation on my part of course!

To answer your original question about how it's supposed to be meant: it won't matter one jot what any investors he once met may think or not think about his lifestyle choices if he's trying to impose a fantasy on his wife.