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Comment by portaouflop | Hacker News Reader

Every human brain is different, some smoke a lot of pot and develop serious mental issues— others smoke a ton for years and you don’t notice any change.

The problem imo with this kinds of studies is that people can’t take the nuance and rather see it as “weed = bad” or some other binary outcome.

Imo all drugs have a potential to be dangerous — all adults should have free agency what they do with their bodies.

Sure cannabis, alcohol or mushrooms are dangerous, but I would argue a society that makes their use completely illegal without nuance is not a free society

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It's very interesting. I am extremely sensitive to THC, in a way I am not to any other drugs. A small amount (5mg) gives me full on disassociation/derealization, very anxious thoughts, etc.

I always wondered if other people had the same experience of THC as I did, but responded _psychologically_ differently to me, or if it was a _physiologically_ different experience. It was very confusing during high school.

Bizarrely I've found this react to weed much more common in the UK than California. There would be no reason for that to be true, though.

> I am extremely sensitive to THC, in a way I am not to any other drugs. A small amount (5mg)

5mg is not a small amount for someone without tolerance.

An old chemistry major college friend went into the THC industry. His company was very careful about production, measurement, and labeling.

He said it was very common for people to tell him that they needed some high number of milligrams to feel anything, then they’d ask him for samples from his company. They’d take what they thought was their normal dose and get completely knocked out.

A lot of products are (or were in the past) apparently very optimistic about their THC content. 5mg is actually a significant dose for most people without tolerance.

> I always wondered if other people had the same experience of THC as I did, but responded _psychologically_ differently to me, or if it was a _physiologically_ different experience. It was very confusing during high school.

I wonder this too. Maybe, say, non-autistic people would interpret differently what I see as mild dissociation, and experience all of the... whatever the fuck THC is supposed to do to Normal People. Or so the theory goes.

> A small amount (5mg) gives me full on disassociation/derealization, very anxious thoughts, etc

It is pretty common for people to have panic attacks while using cannabis. Those can be the symptoms of a panic attack.

> There would be no reason for that to be true, though.

Concentration, cannabinoid composition, adulteration (analogues, enhancement, etc), contamination (heavy metals, pesticides, mold, environmental or biotic toxins) are a few things that come to mind.

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