6502 was my first assembly, though we didn't have an assembler - we entered raw opcodes into the Epyx FastLoad monitor on the C64. You kids with your symbol tables and your fancy mnemonics.
a9 01 8d 20 d0 a9 93 20 d2 ff ...
When we got a KIM-1, we were able to write meaningful programs on it in a weekend, since we already had memorized all the hex.