Absolutely terrible take -- strong subjectivity and defeatist sentiment.
> While in actuality reality can and will go on without humanity.
Sure but in that case you won't be here to consider it. There's no considering such a situation, so there's no use considering such a situation. Push onwards!
> As if the constant string of inconsistencies in quantum physics wasn't proof enough of the ineffectiveness of mathematics as well as science in achieving knowledge.
We're never going to understand everything about everything. That is half the fun! How you got from there to "Humans are physiologically incapable of doing or understanding anything significant" is beyond me.
Stop paying attention to quantum mechanics, and start paying attention to what's important to you. The kinds of things that made you truly happy as a child. Make model train sets or 7 day roguelikes. Make box fortresses for your cats. Make your neighbors lives a little bit better. Talk to a neighbor you've never talked to about the weather or something.