NVRAM must maintain atomicity of memory transactions for power failures. Its whole purpose is to store data when you turn your computer off. As a result, when deleteing an EFI variable, you can't manage the individual bytes - you have to delete a whole entry (which can be rather large - based on the EFI specification and the code used for edk2, e.g. https://github.com/tianocore/edk2/blob/83a86f465ccb1a792f5c5...). Deleting these entries might become a problem when you start running against memory constraints and what slots in memory are actually available; hence a possible fragmentation issue.
Additionally, I appreciated how short and specific this blog post was. I enjoy this style of post of someone encountering a problem and solving it.