Cloud vms are a main target for unikernels, however, as Russ mentions in one of the linked issues there actually is quite a lot of other code you need to include in your system depending on what you are deploying to.

For instance systems with arm64 might need UEFI or if you enable SEV now you need additional support for that which is why I'd agree with Russ's stance on this.

Every time someone asks us to provide support for a new cloud instance type (like a graviton 4 or azure's arm) we have to go in and sometimes provide a ton of new code to get it working.