I started a software job in 1995, writing a lot of code. By mid-1997, I had severe nerve pain in both wrists, even with ice, stretching, and ibuprofen.
I went to an excellent orthopedist who prescribed two things: a Kinesis Advantage keyboard to mostly immobilize the wrists while typing, and 50 mg of Vitamin B6 per day.
The combination saved my career. I sometimes get out of the habit of taking the B6 for a week or two, out of sheer forgetfulness. After a couple of weeks, I'll start noticing very minor nerve pain if I'm using the Kinesis Advantage keyboard (I'm typing this on one right now.) But if I'm typing on a normal keyboard at a client site, a week or so is enough to bring back noticeable nerve pain, which reminds me to start the B6 regimen again. After a few days on B6, the pain recedes.
I was a little nervous at taking 2500% of the RDA, so I researched the medical literature, and the studies I found showing problems caused by excessive B6 all described people taking 200mg or more per day.
The article notes that "since 2022 the TGA has required a warning label for listed medicines with more than 10mg of B6." So maybe studies showing the potential for harm have come out since then; I don't know. On the other hand, has anyone ever gathered data to show whether supplemental B6 actually does improve cases like mine? Vitamin B6 can't be patented, so there's no money to be made, so who is going to fund that study?