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> For example, one of von Braun’s designs called for a massive 75 metre diameter wheel

That’s a radius of about 5% of the length of a human body, so I guess we would soon find out how humans react to living in an environment where ‘gravity’ at eye height is about 5% lower than at toe height or do we already know something about that?

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Some people would lose their lunch, but that's nothing new for space flight. It's just a much more mellow version of classic carnival rides.

I know it’s nothing vs a rollercoaster, but people don’t regularly spend 24 × 7 in rollercoasters.

Not regularly, but there have been contests to see how long people will stay on a rollercoaster. Speaking from some experience, after you've gone around a few times, it can actually get rather boring.

I once had a job making ride photo systems for rollercoasters and rode them repeatedly to make sure the cameras and lighting worked appropriately. And, after riding for several hours late at night, I found myself falling asleep on a roller coaster!

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