My very rusty physics tells me that walking one way along the inside of the wheel would make you weigh less, and the other way would make you weigh more - is this what you're referring to? Would trying to work 'normally' in this kind of situation induce nausea, or make your food fall off your tray etc? It would be a shame if you went to all the effort to make a Von Braun wheel in space to simulate gravity, only to find that you had to stand still to do anything practical.

(I assume the astronauts in 2001 A Space Odyssey jogged in the direction that made themselves weigh more, to make their workout more intense.)