Am I crazy for having my default interactive shell "/bin/env python" point to a virtual environment with all the random dependencies that my one off scripts need, so I can just run "python oneoneoff.py"? All of my one off scripts combined use maybe a dozen dependencies. If I need more, I just install them there. I use pyenv, so it's trivial to change the version of python that the interactive shell uses (default or temporary within the current shell).

From my perspective, people seem to make it difficult to use python, more from not understanding the difference between interactive shell and non-interactive shell configurations (if you think the above breaks system tools that use python, then you don't understand the difference, nor that system tools use /bin/python rather than /usr/env python), with a bit of cargo-cult mixed in, more than anything.