Very.
It's possible to make no mistake and still lose.
My wife got hit-and-run when bicycling to work and she's exceeding careful and defensive in her riding.
Her carefulness is probably what allowed her to catch a glimpse of the car in the corner of her eye and swerve at the last minute to not be caught head-on by the car and sent flying hundreds of meters away.
She's "lucky" to even have made it, suffering debilitating neck pain every day and night, abated only by roughly a half through invasive surgery, a pain she will have to endure for the rest of her life which at the current rate of life expectancy is the next fifty years.
Meanwhile the distracted and hurried driver who didn't bother to check around their A pillar blind spot drove away scot-free.
That's one example. I have many such stories of cyclist and biker friends alike, many of which don't ever ride between lanes.