I'm not sure if there's software out there to make that process easy, but the format allows for it. The format also allows for someone to produce and sign one version and someone else to adjust that version and sign the new changes.
Funnily enough, the PDF signature actually has a field to refer to a (picture of) a readable signature in the file, so software can jot down a scan of a signature that automatically inserts cryptographic proof.
In practice I've never seen PDFs signed with more than one signature. PDF readers from anyone but Adobe seem to completely ignore signatures unless you manually open the document properties, but Adobe Reader will show you a banner saying "document signed by XYZ" when you open a signed document.