Also, the VAX instruction encoding is a class of horror above that of x86.
Only ISA where I've seen a single instruction span two memory pages despite being page aligned
Maximum instruction length is 56 bytes. Early models had 8 byte cache lines, later ones 64 bytes. VM page 512 bytes.
What I am more certain of was complaints about possibly ending with maaaany TLB lookups (and pagetable walks) for certain "business" optimized instructions.
[1] MOVTC (Move Translated Character), MOVTUC (Move Translated Until Character), ADDP6 (Add Packed 6-operand)