Or even more fundamentally, that physics captures all physical phenomena, which it doesn't. The methods of physics intentionally ignore certain aspects of reality and focus on quantifiable and structural aspects while also drawing on layers of abstractions where it is easy to mistakenly attribute features of these abstractions to reality.
To me it seems highly likely that our knowledge of physics is more than sufficient for simulating the brain, what is lacking is knowledge of biology and the computational power.
Ok - I get that bit. I have always thought that physics is a description of the universe as observed and of course the description could be misleading in some way.
>the methods of physics intentionally ignore certain aspects of reality and focus on quantifiable and structural aspects
Can you share the aspects of reality that physics ignores? What parts of reality are unquantifiable and not structural?
Here's an article you might enjoy [0].
[0] http://edwardfeser.blogspot.com/2022/05/the-hollow-universe-...