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Comment by JumpCrisscross | Hacker News Reader

> due the fact bacteria and phages are coevolving, hence any phage treatment is highly specific and hence not worth of developing

How is this different from antibiotics?

Nothing about phages makes them not worth developing. Exhibit A: they’re being researched and developed.

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1) Phages are specific for each bacteria species or sub-species. Can't treat E.coli and Klebsiella with the same phages like we do with antibiotics. Not even the test kits are the same. There are hundreds of phages for each bacteria species and only a few of them would work for each patient.

2) Phages are live organisms (as much as you can call a virus "alive"). The shelf life is very very short. A couple of days probably.

1 + 2 => A hospital would have to store thousands of different phages to be able to treat most of it's patients and it would have to replace those stores twice a week.

> hospital would have to store thousands of different phages to be able to treat most of it's patients and it would have to replace those stores twice a week

Couldn’t you create a few compound batches that treat sets of bacteria, balancing distribution cost and side effects?

Do that a little, remove phages that don’t work better than antibiotics, tailor for local conditions and I doubt you’re adding more than a few dozen medicines to the hospital’s inventory.

> shelf life is very very short. A couple of days probably

Plenty can survive cryogenic suspension [1].

[1] https://pmc.ncbi.nlm.nih.gov/articles/PMC3131515/

They are only active against a narrow strain of bacteria unlike antibiotics.

> are only active against a narrow strain of bacteria unlike antibiotics

And this makes them “not worth…developing” why?

(The comparison to antibiotics was that the antibiotic-bacteria system is coevolving too. Exhibit A: TFA on antibiotic resistance.)

Much slower, we are still using 100 year old antibiotics. Money one phage is going to make is much smaller. This is not cost effective to go through the whole process.

> Money one phage is going to make is much smaller

Again, what are you basing this on?

> This is not cost effective to go through the whole process

Now do personalized medicine.

Phages are binding to very specific proteins, where as antibiotics disrupt more fundamental processes.

Personal medicine as in individual combination of existing drugs is easier to achieve in current regulatory framework then using new drugs.

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