So much so in fact, Microsoft developed NT 3.1 first on non-x86 architectures (i860 and MIPS), then later ported to x86, to ensure no x86 specific code made it in.
NT supported quite a few architectures:
> https://en.wikipedia.org/wiki/Windows_NT#Supported_platforms
"Windows NT 3.1 was released for Intel x86 PC compatible and PC-98 platforms, and for DEC Alpha and ARC-compliant MIPS platforms. Windows NT 3.51 added support for the PowerPC processor in 1995"...
NT is a pretty interesting bit of PC history, I can highly recommend the book "Show Stopper!" by G. Pascal Zachary that recounts its development, and also dives a bit into why making the OS portable across CPU architectures was so important to the team at the time.