Lot of that Despair is thanks to how the architecture of the chimp brain handles unpredictability over different time horizons - whats the system going to do tomorrow/next month/next year/next decades. Confidence decreases anxiety increases. You want to break the architecture keep feeding it the unpredictable.
So we get the corporal hudson in aliens cycle - "I'm ready, man. Check it out. I am the ultimate badass. State of the badass art" > unpredictability > "Whats happening man! Now what are we supposed to do? Thats it man. Game over man. Game over!"
Think about what science offers corporal hudson.