Yes, the distances are mind-boggling. There are a few somewhat realistic solutions for making such a trip in the forseeable future. If you send something of significant mass, it is certain to take a long time. So we're either talking generation ships(§), embryo space colonization (growing into adults en route or at destination) or hibernation. That or a breakthrough in fundamental physics.

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(§) Something like O'Neill cylinders with fusion as energy source could work