(commentary: things are really moving too fast for the layperson to keep up)
Typically, input gets routed to a number of of experts eg. top 2, leaving the others inactive. This reduces number of activation / processing requirements.
Mistral is an example of a model that's designed like this. Clever people created converters to transform dense models to MOE models. These days many popular models are also available in MOE configuration
I'm not saying it is a perfect analogy, but it is by far the most familiar one for people to describe what sparse activation means. I'm no big fan of over-reliance on biological metaphor in this field, but I think this is skewing a bit on the pedantic side.
re: your second comment about pruning, not to get in the weeds but I think there have been a few unique cases where people did lose some of their brain and the brain essentially routed around it.
MOE is not the holy grail, as there are drawbacks eg. less consistency, expert under/over-use