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I feel like programmers use semi-colons more often; we're more familiar with them.

Erlang (and probably Prolog, but my memories there are fuzzy) use periods, commas, and semi-colons in a directly analogous way to English.

I wonder if there are languages of programming that use em-dashes?

APL seemed the likeliest candidate, but no such luck.

true, perhaps, but a colon would have been more appropriate here and programmers should be familiar enough with them also.