Recently, things have been advancing which may finally allow a seamless virtualization experience on the Linux desktop (and match QubesOS in some security aspects).

GPU drivers supporting native contexts with Mesa support.

Wayland sharing between guest and host. It used to be somewhat sloppy (involved protocol parsing; sommilier & wayland-proxy-virtwl) but recently someone undertook a project to do it properly that may soon bear fruit: https://codeberg.org/drakulix/wl-cross-domain-proxy

A VMM to utilize these features: https://github.com/AsahiLinux/muvm

And a solution which ties these things together: https://git.clan.lol/clan/munix