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So use Perl :)

The thing about Perl is that there is supposed to be more than one way to do it. Which enables you to mix-and-match different paradigms in a way that the Python philosophy doesn't seem to welcome.

Or just use a Lisp.

Perl 6 even comes with hygienic macros, I believe. That should be much nicer than source filters in Perl 5.

Perl 5 actually has several ways of doing macros without using source filters -- pragmas are one example.

I'm pretty sure I seen someone doing python macros using a custom codec: http://docs.python.org/library/codecs.html

I'd suggest that metaclasses are Python's 'equivalent' for magically mutating things.