Not really... Most F150s have a 5.5' bed which is pathetically small. You can't fit a sheet of plywood or a 2x4 in there without having the tailgate down. You can only really buy full-sized long box trucks if you're part of a fleet program.

Most professional builders drive big Savannah vans, which can not only carry full sheets of plywood, but also keep them dry. Plus, the front blindspot is less than one meter.

I don't disagree about transit though.