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Can you talk a bit more about situations where WHO or UNESCO have overridden a country's health system? As a US citizen I see WHO as 1) offering guidance and 2) funding programs in poorer countries' health systems.

UNESCO, well, I'm looking at its website and Wikipedia article now, and I don't understand what it does. (Or maybe it would be easier to list what it doesn't do, since even its list of sponsored institutions is mind-numbingly long.)

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UNESCO claims to protect things of historical and cultural importance. Like good health, this sounds a noble goal in itself. In practice it is often more of a junket/gravy train, as are most of these NGOs.

The WHO has been trying to push through an international treaty since 2020 which would allow them to override national governments on health matters.

Which countries give up their sovereignty when they sign treaties?

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