I look at pull requests daily, I haven't encountered the problems you speak of, not sure what they are.
If you want a practical example, here you go. I'm a Nixpkgs commiter and every time I make a pull request that backports some change to the stable branch, GitHub unprompted starts comparing my PR against master. If I'm not fast enough to switch the target branch within a couple of seconds it literally freezes the browser tab and I may have to force quit it. Yes, the diff is large, but this is not acceptable, and more importantly, it didn't happen a few years ago.