> Unless you were forced to by some organisational policy, there’s no point setting up 2FA only to reduce the effective security to 1FA because of convenience features.
2FA both stored in your password manager is less secure than storing than separately, but it still offers security compared to a single factor. The attack methods you mentioned (RAT, keylogger) require your device to be compromised, and if your device is not compromised 2fa will help you.
To slip into opinion mode, I consider my password manager being compromised to be mostly total compromise anyway.
Also I really like the style and font of your blog.