Lets hope more people switch to roccat mice. Roccat[1] is the only vendor that I know of with actual Linux support[2].
[2] http://www.phoronix.com/scan.php?page=news_item&px=ODY1M...
[2] http://www.phoronix.com/scan.php?page=news_item&px=ODY1M...
That said, I use a death adder, a mamba, a lachesis, and an Orochi with Linux just fine. Admittedly I don't have the advantages of advanced configurations, but that's what you get without An Internet connection with Synapse 2.0 anyway.