I've worked with ROCCAT for years (as well as other companies like Razer) and never heard about this before. How do other gaming mice do on linux if they haven't focused on supporting it?
That said, I use a death adder, a mamba, a lachesis, and an Orochi with Linux just fine. Admittedly I don't have the advantages of advanced configurations, but that's what you get without An Internet connection with Synapse 2.0 anyway.