Toilets are unglamorous in the extreme but absolutely vital. Humans make hazardous and potentially deadly waste. Every day. It needs to be safely discarded/contained. In a sealed environment in microgravity it's even more dangerous than it is on Earth.
Aerosolized fecal matter can enter the lungs and cause deadly infections. Entering the digestive system can cause debilitating (possibly deadly) illness. Temporary blindness if it gets in the eyes. It can also cause mechanical or electrical problems if it gets in equipment. All of these can lead to a mission failure and in extreme instances a total loss of the crew. Apollo 8 was extremely lucky that Frank Borman's illness didn't cause more problems.
If you're not thinking logistics and infrastructure you're not really serious about an endeavor.
[0] https://www.smithsonianmag.com/arts-culture/why-did-van-hale...