Would you mind sharing a little about how your wife does business? Like, are her clients regular people or art shops? How does she put a price on her work?
She also has a few art shows she applies to and goes presents at those. I think this is where most of her recurring customers come from honestly, and not Instagram. Though she has had a few commissions from Instagram.
A side note on those looking to buy art, you might refrain from asking for a custom piece. If you see something you like, there's a good chance you don't know why you like it even if you think you do. So when you give the artist a picture you want them to translate into something like oil, it'll probably disappoint. The frustrations I've seen my wife go through trying to get a commission right is tiring.