This was an interesting interview. Like a lot of great comedians, Odenkirk has a very grounded and bleak view of the world. I suppose a lot of art, comedy included, is a way of coping with their perspective, for themselves and for the audience.
IIRC, I've heard it said that comedians are not happy people and usually had pretty difficult childhoods where "being funny" was a coping mechanism.
Most of timeless comedy simply describes the mundane reality of the audience in a way that they realize the absurdity of it.
Such people have different perspectives on life, success and happiness, for better or worse.