Episodes started veering into niche discussions specific to iOS developers (see the episode on in-app vs. iOS-level settings). Occasionally Marco and Dan would discuss the mobile market but their opinions are established after >100 episodes, so we never saw any surprises there. The overall effect, though, was a show that felt "ready."
I'm one of the people that emailed or tweeted at Marco whenever I disagreed with him, but I'll miss this show. B&A started two years ago when I was just wrapping my head around Python, and I really enjoyed hearing people geek out about development (and coffee and cars and...) during a time when I was just realizing that an engineer's life doesn't mean writing some terrible language alone in a cubicle.
Thanks to these guys for the good run. Siracusa will have to fly the geek banner a bit higher now.