Kappa-opioid receptor activation causes a person to feel intense dissociative dysphoria. Pretty much the opposite of why people use opioids.
Opioid use has been associated with numerous psychiatric symptoms, including dissociative symptoms.
Menthol, for example, only activates the kappa receptor: accidentally overdosing on pure menthol felt to me like immediate doom was approaching and nothing would ever again be fine.
I don’t eat anything menthol-flavored any more. It seems like an operant conditioning agent masquerading as a flavor.